Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae

被引：52

作者：

Garcia-Ranea, JA ^{[1
]}

Valencia, A ^{[1
]}

机构：

[1] CSIC, CNB, Prot Design Grp, E-28049 Madrid, Spain

来源：

FEBS LETTERS | 1998年 / 434卷 / 03期

关键词：

ras; p21; yeast; genome; Saccharomyces cerevisiae;

D O I：

10.1016/S0014-5793(98)00967-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recent availability of the full Saccharomyces cerevisiae genome sequence offers a first opportunity to analyze the composition, function and evolution of GTPases in the ras-p21 superfamily, This superfamily in yeast is composed of 29 proteins divided into five families: ras with four sequences implicated in cell signalling; rho, six genes related to the cell shape machinery; ypt-rab, ten proteins with different roles in intracellular trafficking; arf-sar, seven proteins related to vesicular trafficking in secretory pathways; and ran, two proteins acting as components of the nuclear transport system. The superfamily covers a wide range of cellular functions from signalling to intracellular trafficking, while conserving the structural framework and a common mechanism of GTP hydrolysis, (C) 1998 Federation of European Biochemical Societies.

引用

页码：219 / 225

页数：7