Molecular aspects on the interaction of quercetin and its metal complexes with DNA

被引：69

作者：

Dolatabadi, Jafar Ezzati Nazhad ^{[1
]}

机构：

[1] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2011年 / 48卷 / 02期

关键词：

Flavonoid; Quercetin; DNA; Intercalation; Outside binding; ANTIOXIDANT FLAVONOIDS; PROTECTIVE ACTION; DAMAGE; BINDING; RNA; NICKEL; REPAIR;

D O I：

10.1016/j.ijbiomac.2010.11.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Flavonoids occupy an important position in chemistry and pharmacology. Various flavonoids, particularly quercetin have potential to form molecular complexes with nucleic acid structure and have attracted recent attention for their prospective clinical and pharmacological utility. This review highlights the properties of quercetin and its different metal complexes as well as their interactions with DNA reported by several research groups. Various analytical techniques were employed including absorbance, fluorescence and circular dichroism spectroscopies, viscosity and voltammetry to provide more details about binding mechanism of these materials with DNA. (C) 2010 Elsevier B.V. All rights reserved.

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页码：227 / 233

页数：7

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