Enantioselective epoxidation of α,β-enones promoted by α,α-diphenyl-L-prolinol as bifunctional organocatalyst

被引:121
作者
Lattanzi, A [1 ]
机构
[1] Univ Salerno, Dipartimento Chim, I-84081 Baronissi, Italy
关键词
D O I
10.1021/ol050694m
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An operationally simple and mild protocol for the catalytic enantioselective epoxiclation of alpha,beta-unsaturated ketones has been estabilished using commercially available a,a-diphenyl-L-prolinol as bifunctional organocatalyst and tert-butyl hydroperoxide (TBHP) as oxidant. The epoxides have been obtained in good yields and with up to 80% ee.
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页码:2579 / 2582
页数:4
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