Synthesis of unsaturated lactone moieties by asymmetric hetero Diels-Alder reactions with binaphthol-titanium complexes

被引：50

作者：

Quitschalle, M ^{[1
]}

Christmann, M ^{[1
]}

Bhatt, U ^{[1
]}

Kalesse, M ^{[1
]}

机构：

[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(00)02213-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Natural products like ratjadone and callystatin A contain an alpha,beta -unsaturated lactone moiety which adds to the biological activity of these compounds. Here we report a rapid and practical access to lactone precursor 3 by an asymmetric hetero Diels-Alder reaction as the key step and its subsequent transformation into a suitable building block 4. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1263 / 1265

页数：3

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