High yield [125I]iodide-labeling of iodinated carboranes by palladium-catalyzed isotopic exchange

被引：21

作者：

Winberg, KJ

Barberà, G

Eriksson, LB

Teixidor, F

Tolmachev, V

Viñas, C

Sjöberg, S

机构：

[1] Uppsala Univ, Inst Chem, Dept Organ Chem, S-75124 Uppsala, Sweden

[2] CSIC, Inst Ciencia Mat Barcelona, Barcelona 08193, Spain

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2003年 / 680卷 / 1-2期

关键词：

isotopic exchange; iodinated carboranes; I-125]iodide; labeling; palladium; catalyst;

D O I：

10.1016/S0022-328X(03)00344-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We have recently shown the feasibility of palladium-catalyzed isotopic exchange between [I-125]iodide and 2-iodo-para-carborane. In this work we have modified the methodology and extended its application to a wider range of iodinated carboranes. Thus, by using Herrmann's catalyst in toluene at 100 degreesC, 2-I-p-, 3-I-o-, 9-I-o-, 9-I-m-carborane, 1-phenyl-3-I-o-carborane and 1,2-diphenyl-3-I-o-carborane have been radiolabeled with (125)iodine in high to excellent yields. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：188 / 192

页数：5

共 9 条

[1] Retention of the B(3)-X (X Br, I) bond in closo-o-carborane derivatives after nucleophilic attack.: The first synthesis of [3-X-7-R-7,8-nido-C2B9H10]- (X Br, I).: Crystal structure of [HNMe3][3-I-7,8-nido-C2B9H11] [J].