Polyhedral boron compounds as potential linkers for attachment of radiohalogens to targeting proteins and peptides.: A review

被引：41

作者：

Tolmachev, V

Sjöberg, S

机构：

[1] Uppsala Univ, Dept Organ Chem, SE-75121 Uppsala, Sweden

[2] Uppsala Univ, Rudbeck Lab, SE-75185 Uppsala, Sweden

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2002年 / 67卷 / 07期

关键词：

tumour targeting; I-123; I-125; Br-76; At-211; polyhedral boron clusters; prosthetic groups; boranes; carboranes; isotope labelling;

D O I：

10.1135/cccc20020913

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.

引用

页码：913 / 935

页数：23

共 91 条

[1] BORONATION OF ANTIBODIES WITH MERCAPTOUNDECAHYDRO-CLOSO-DODECABORATE(2-) ANION FOR POTENTIAL USE IN BORON NEUTRON-CAPTURE THERAPY [J].