Drug-induced acute kidney injury in the critically ill adult: Recognition and prevention strategies

被引：88

作者：

Bentley, Michael L. ^{[1
]}

Corwin, Howard L. ^{[2
]}

Dasta, Joseph ^{[3
,4
]}

机构：

[1] Roanoke Mem Hosp, Carilion Clin, Dept Pharm Serv, Roanoke, VA 24013 USA

[2] Dartmouth Hitchcock Med Ctr, Dept Anesthesiol, Sect Crit Care Med, Lebanon, NH 03766 USA

[3] Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA

[4] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA

来源：

CRITICAL CARE MEDICINE | 2010年 / 38卷

关键词：

acute kidney injury; acute kidney failure; drug-induced; ACUTE-RENAL-FAILURE; CONTRAST-INDUCED NEPHROPATHY; AMPHOTERICIN-B NEPHROTOXICITY; AMINOGLYCOSIDE NEPHROTOXICITY; RISK-FACTORS; OUTCOMES; INSUFFICIENCY; THERAPY; PATHOPHYSIOLOGY; EPIDEMIOLOGY;

D O I：

10.1097/CCM.0b013e3181de0c60

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Acute kidney injury is common in critically ill patients, with an incidence of 20% to 30%. It has been associated with increased mortality, hospital length of stay, and total cost. A number of strategies may be beneficial in identifying at-risk patients. In addition, using preventive measures and avoiding nephrotoxic medications are paramount in reducing the overall incidence. Although multifactorial, drug-induced acute kidney injury may account for up to 25% of all cases of acute kidney injury in this population. This review focuses on the mechanisms of drug-induced acute kidney injury in critically ill adults and offers preventive strategies when appropriate. (Crit Care Med 2010; 38[Suppl.]:S169-S174)

引用

页码：S169 / S174

页数：6

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