Synthesis of furanomycin derivatives by gold-catalyzed cycloisomerization of α-hydroxyallenes

被引：44

作者：

Erdsack, Joerg ^{[1
]}

Krause, Norbert ^{[1
]}

机构：

[1] Univ Dortmund, D-44227 Dortmund, Germany

来源：

SYNTHESIS-STUTTGART | 2007年 / 23期

关键词：

allenes; amino acids; cycloisomerization; furanomycin; gold catalysis;

D O I：

10.1055/s-2007-990860

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel furanomycin analogues 8 and 17 were synthesized as mixture of two diastereomers using the gold-catalyzed cycloisomerization of alpha-hydroxyallenes as the key step. Compared to the traditional use of stoichiometric amounts of silver salts, gold catalysis is much more efficient for the cyclization of highly functionalized substrates.

引用

收藏

页码：3741 / 3750

页数：10

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