The Many Faces of Tau

被引：660

作者：

Morris, Meaghan ^{[1
,2
]}

Maeda, Sumihiro ^{[1
,3
]}

Vossel, Keith ^{[1
,3
]}

Mucke, Lennart ^{[1
,3
]}

机构：

[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Biochem Cellular & Mol Biol Grad Program, Baltimore, MD 21205 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA

来源：

NEURON | 2011年 / 70卷 / 03期

关键词：

PAIRED HELICAL FILAMENTS; TRANSGENIC MOUSE MODEL; A-BETA OLIGOMERS; SMALL-MOLECULE INHIBITORS; PHOSPHOLIPASE C-GAMMA; ALZHEIMERS-DISEASE; PROTEIN-TAU; AMYLOID-BETA; NEUROFIBRILLARY TANGLES; IN-VIVO;

D O I：

10.1016/j.neuron.2011.04.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.

引用

页码：410 / 426

页数：17

共 187 条

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