The Many Faces of Tau

被引:660
作者
Morris, Meaghan [1 ,2 ]
Maeda, Sumihiro [1 ,3 ]
Vossel, Keith [1 ,3 ]
Mucke, Lennart [1 ,3 ]
机构
[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA
[2] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Biochem Cellular & Mol Biol Grad Program, Baltimore, MD 21205 USA
[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA
关键词
PAIRED HELICAL FILAMENTS; TRANSGENIC MOUSE MODEL; A-BETA OLIGOMERS; SMALL-MOLECULE INHIBITORS; PHOSPHOLIPASE C-GAMMA; ALZHEIMERS-DISEASE; PROTEIN-TAU; AMYLOID-BETA; NEUROFIBRILLARY TANGLES; IN-VIVO;
D O I
10.1016/j.neuron.2011.04.009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.
引用
收藏
页码:410 / 426
页数:17
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