Role of Toll like receptor-activated dendritic cells in the development of autoimmunity

被引：9

作者：

Granucci, Francesca ^{[1
]}

Zanoni, Ivan ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Biosci & Biotechnol, I-20126 Milan, Italy

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷

关键词：

Toll-like receptors; endogenous Toll-like receptor ligands; exogenous Toll-like receptor ligands; dendritic cells; autoimmunity; type I interferons; review;

D O I：

10.2741/3041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recognition of microbial stimuli by Toll-like receptors (TLRs) expressed on dendritic cells (DCs) is essential for the regulation of immune responses. DC activation via TLRs leads to the production of proinflammatory cytokines, chemokines and surface molecules that play a key role in the regulation and control of inflammatory reactions and adaptive immunity. Minor imbalances in the feedback control of TLR-activated innate immune cells have been associated with autoimmunity in genetically prone individuals. We review here recent studies indicating how TLR-mediated activation of innate immune cells, including DCs, may be involved in the development and/or maintenance of autoimmune responses in the presence of both endogenous and exogenous ligands.

引用

收藏

页码：4817 / 4826

页数：10

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