A Toll-like trigger for autoimmune disease

被引：15

作者：

Bach, JF ^{[1
]}

机构：

[1] Inst Natl Sante & Rech Med, F-75015 Paris, France

来源：

NATURE MEDICINE | 2005年 / 11卷 / 02期

关键词：

D O I：

10.1038/nm0205-120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autoimmune disease is set in motion by certain triggers, one of which now comes to light in a mouse model of type 1 diabetes. Signaling through Toll-like receptors, known for receiving signals from viruses and bacteria, initiates the disease (pages 138-145).

引用

收藏

页码：120 / 121

页数：2

相关论文

共 15 条

[1] Diversity of regulatory CD4+ T cells controlling distinct organ-specific autoimmune diseases [J].

Alyanakian, MA ;

You, S ;

Damotte, D ;

Gouarin, C ;

Esling, A ;

Garcia, C ;

Havouis, S ;

Chatenoud, L ;

Bach, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :15806-15811

[2] Interferon-α in systemic lupus erythematosus [J].

Crow, MK ;

Kirou, KA .

CURRENT OPINION IN RHEUMATOLOGY, 2004, 16 (05) :541-547

[3]

FOULIS AK, 1987, LANCET, V2, P1423

[4] Induction of clinical autoimmune disease by therapeutic interferon-α [J].

Gota, C ;

Calabrese, L .

AUTOIMMUNITY, 2003, 36 (08) :511-518

[5] Type I IFN protects against murine lupus [J].

Hron, JD ;

Peng, SL .

JOURNAL OF IMMUNOLOGY, 2004, 173 (03) :2134-2142

[6] TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease [J].

Kerfoot, SM ;

Long, EM ;

Hickey, MJ ;

Andonegui, G ;

Lapointe, BM ;

Zanardo, RCO ;

Bonder, C ;

James, WG ;

Robbins, SM ;

Kubes, P .

JOURNAL OF IMMUNOLOGY, 2004, 173 (11) :7070-7077

[7] Inhibition of lupus by genetic alteration of the interferon-α/β receptor [J].

Kono, DH ;

Baccala, R ;

Theofilopoulos, AN .

AUTOIMMUNITY, 2003, 36 (08) :503-510

[8] Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease [J].

Lang, KS ;

Recher, M ;

Junt, T ;

Navarini, AA ;

Harris, NL ;

Freigang, S ;

Odermatt, B ;

Conrad, C ;

Ittner, LM ;

Bauer, S ;

Luther, SA ;

Uematsu, S ;

Akira, S ;

Hengartner, H ;

Zinkernagel, RM .

NATURE MEDICINE, 2005, 11 (02) :138-145

[9] Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon [J].

Le Bon, A ;

Etchart, N ;

Rossmann, C ;

Ashton, M ;

Hou, S ;

Gewert, D ;

Borrow, P ;

Tough, DF .

NATURE IMMUNOLOGY, 2003, 4 (10) :1009-1015

[10]

Leadbetter Elizabeth A, 2003, Curr Dir Autoimmun, V6, P105