Anticancer constituents from the roots of Rubia cordifolia L.

被引：83

作者：

Son, Jong Keun

Jung, Soon Ja ^{[1
]}

Jung, Ji Hyun ^{[1
]}

Fang, Zhe ^{[1
]}

Lee, Chong Soon

Seo, Chang Seob

Moon, Dong Cheul

Min, Byung Sun ^{[1
]}

Kim, Mi Ryeo

Woo, Mi Hee ^{[1
]}

机构：

[1] Catholic Univ Daego, Coll Pharm, Gyeongbuk 712702, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 02期

关键词：

Rubia cordifolia L; epoxymollugin; topoisomerase; cytotoxicity;

D O I：

10.1248/cpb.56.213

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Activity-directed isolation of the methylene chloride fraction of the roots of Rubia cordifolia L. resulted in the identification of a new epoxymollugin (3) and eight known compounds (1, 2, 4-9). The structures of the compounds were elucidated from chemical and spectroscopic evidence. In addition, their topoisomerase I and II inhibitory activities and cytotoxicities were measured.

引用

页码：213 / 216

页数：4

共 15 条

[1]

Ali AM, 2000, PHARM BIOL, V38, P298, DOI [10.1076/1388-0209(200009)3841-AFT298, 10.1076/1388-0209(200009)38:4

[2]

1-A

[3]

FT298]

[4] NOVEL ANTHRAQUINONES FROM UNDIFFERENTIATED CELL-CULTURES OF GALIUM-VERUM [J].

BANTHORPE, DV ;

WHITE, JJ .

PHYTOCHEMISTRY, 1995, 38 (01) :107-111

[5] C-13 NUCLEAR MAGNETIC-RESONANCE STUDIES OF ANTHRAQUINONES .2. HYDROXYMETHOXYANTHRAQUINONES, ACETOXYMETHOXYANTHRAQUINONES AND NATURALLY-OCCURRING ANTHRAQUINONE ANALOGS [J].

BERGER, Y ;

CASTONGUAY, A ;

BRASSARD, P .

ORGANIC MAGNETIC RESONANCE, 1980, 14 (02) :103-108

[6] ANTIPLATELET CONSTITUENTS OF FORMOSAN RUBIA AKANE [J].

CHUNG, MI ;

JOU, SJ ;

CHENG, TH ;

LIN, CN ;

KO, FN ;

TENG, CM .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (02) :313-316

[7]

Fukuda M, 1996, CANCER RES, V56, P789

[8]

HAN B H, 1990, Archives of Pharmacal Research (Seoul), V13, P289, DOI 10.1007/BF02856539

[9]

ITOKAWA H, 1983, CHEM PHARM BULL, V31, P2353

[10] ANTHRAQUINONES, NAPHTHOQUINONES AND NAPHTHOHYDROQUINONES FROM RUBIA-ONCOTRICHA [J].

ITOKAWA, H ;

QIAO, YF ;

TAKEYA, K .

PHYTOCHEMISTRY, 1991, 30 (02) :637-640

← 1 2 →