A light and electron microscopic study of cytoplasmic phospholipase A2 and cyclooxygenase-2 in the hippocampus after kainate lesions

被引：103

作者：

Sandhya, TL

Ong, WY ^{[1
]}

Horrocks, LA

Farooqui, AA

机构：

[1] Natl Univ Singapore, Dept Anat, Singapore 119260, Singapore

[2] Ohio State Univ, Dept Med Biochem, Columbus, OH 43210 USA

来源：

BRAIN RESEARCH | 1998年 / 788卷 / 1-2期

关键词：

excitotoxicity; phospholipase A(2); cyclooxygenase-2; arachidonic acid; reactive astrocyte; glial scar; hippocampus;

D O I：

10.1016/S0006-8993(97)01552-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The systemic administration of kainate (10 mg/ml) into adult Wistar rats produces seizures and neurodegeneration. We have studied the effect of kainate administration on cPLA(2) and COX-2 immunoreactivities after 3 days and 1, 2, 4 and 11 weeks. The cPLA(2) immunoreactivity was increased in hippocampal neurons at 1 and 3 days after kainate injection suggesting that PLA, may be involved in neurodegeneration. Increased cPLA(2) and COX-2 immunoreactivities in astrocytes at 1, 2, 4 and 11 weeks after kainate injection indicate an adaptive astrocytic response that may be associated with gliosis. (C) 1998 Elsevier Science B.V.

引用

页码：223 / 231

页数：9