Triammineplatinum(II) coordinated to a guanine does not prevent platination of an adjacent guanine in single-stranded oligonucleotides

被引：24

作者：

Reeder, F ^{[1
]}

Kozelka, J ^{[1
]}

Chottard, JC ^{[1
]}

机构：

[1] UNIV PARIS 05,CHIM & BIOCHIM PHARMACOL & TOXICOL LAB,CNRS,URA 400,F-75270 PARIS 06,FRANCE

来源：

INORGANIC CHEMISTRY | 1996年 / 35卷 / 05期

关键词：

D O I：

10.1021/ic951135m

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Adjacent guanines within single-stranded oligodeoxy-ribonucleotides are shown to bind easily two dicationic platinum centers. This type of cumulative binding, which is favored by high ionic strength, should be taken into account in kinetic studies of metal-DNA interactions, especially when the metal complex is in excess.

引用

页码：1413 / &

页数：4

共 12 条

[1]

[Anonymous], 1980, METAL IONS BIOL SYST

[2]

[Anonymous], METAL IONS BIOL SYST

[3] PLATINATION PATHWAYS FOR REACTIONS OF CISPLATIN WITH GG SINGLE-STRANDED AND DOUBLE-STRANDED DECANUCLEOTIDES [J].

BARNHAM, KJ ;

BERNERSPRICE, SJ ;

FRENKIEL, TA ;

FREY, U ;

SADLER, PJ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (17) :1874-1877

[4] PLATINUM BINDING TO D(GPG) TARGET SEQUENCES AND PHOSPHOROTHIOATE LINKAGES IN DNA OCCURS MORE RAPIDLY WITH INCREASING OLIGONUCLEOTIDE LENGTH [J].

ELMROTH, SKC ;

LIPPARD, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (08) :3633-3634

[5] CROSS-LINKING OF ADJACENT GUANINE RESIDUES IN AN OLIGONUCLEOTIDE BY CIS-[PT(NH3)2(H2O)2]2+ - KINETIC-ANALYSIS OF THE 2-STEP REACTION [J].

GONNET, F ;

KOZELKA, J ;

CHOTTARD, JC .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1992, 31 (11) :1483-1485

[6]

GONNET F, IN PRESS INORG CHEM

[7] MATRIX-ASSISTED LASER-DESORPTION IONIZATION TIME-OF-FLIGHT MASS-SPECTROMETRY OF DNA-PT(II) COMPLEXES [J].

GUITTARD, J ;

PACIFICO, C ;

BLAIS, JC ;

BOLBACH, G ;

CHOTTARD, JC ;

SPASSKY, A .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1995, 9 (01) :33-36

[8]

MORITA H, 1983, INORG SYN, V22, P124

[9] KINETIC INVESTIGATION OF THE DNA PLATINATION REACTION - EVIDENCE FOR A TRANSIENT ADDUCT BETWEEN DEOXYRIBONUCLEIC-ACID AND CIS-PLATINUM(II) [J].

SCHALLER, W ;

REISNER, H ;

HOLLER, E .

BIOCHEMISTRY, 1987, 26 (03) :943-950

[10] STRUCTURAL ASPECTS OF PLATINUM ANTICANCER DRUG-INTERACTIONS WITH DNA [J].

SHERMAN, SE ;

LIPPARD, SJ .

CHEMICAL REVIEWS, 1987, 87 (05) :1153-1181

← 1 2 →