Triammineplatinum(II) coordinated to a guanine does not prevent platination of an adjacent guanine in single-stranded oligonucleotides

被引：24

作者：

Reeder, F ^{[1
]}

Kozelka, J ^{[1
]}

Chottard, JC ^{[1
]}

机构：

[1] UNIV PARIS 05,CHIM & BIOCHIM PHARMACOL & TOXICOL LAB,CNRS,URA 400,F-75270 PARIS 06,FRANCE

来源：

INORGANIC CHEMISTRY | 1996年 / 35卷 / 05期

关键词：

D O I：

10.1021/ic951135m

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Adjacent guanines within single-stranded oligodeoxy-ribonucleotides are shown to bind easily two dicationic platinum centers. This type of cumulative binding, which is favored by high ionic strength, should be taken into account in kinetic studies of metal-DNA interactions, especially when the metal complex is in excess.

引用

页码：1413 / &

页数：4