Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo

被引：70

作者：

Liu, Xiaojuan ^{[1
,2
]}

Luo, Qingxin ^{[1
]}

Rakariyatham, Kanyasiri ^{[2
]}

Cao, Yong ^{[1
]}

Goulette, Timothy ^{[2
]}

Liu, Xin ^{[1
]}

Xiao, Hang ^{[2
]}

机构：

[1] South China Agr Univ, Coll Food Sci, Dept Food Sci, Guangzhou 510642, Guangdong, Peoples R China

[2] Univ Massachusetts, Dept Food Sci, 102 Holdsworth Way, Amherst, MA 01003 USA

来源：

JOURNAL OF FUNCTIONAL FOODS | 2016年 / 25卷

关键词：

Astaxanthin; Stereoisomeric; Antioxidation; Anti-ageing; Cellular antioxidant activity; Caenorhabditis elegans; TROUT ONCORHYNCHUS-MYKISS; CAENORHABDITIS-ELEGANS; C-ELEGANS; LIFE-SPAN; GENE-EXPRESSION; ALL-E; DAF-16; MODEL; PIGMENTATION; CAROTENOIDS;

D O I：

10.1016/j.jff.2016.05.009

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Astaxanthin (AST) is a potent antioxidant with different stereoisomers in nature. However, there have been no reports about the functional activities of different stereoisomers so far. In this study, the antioxidant and anti-ageing activities of 3S,3'S (S), 3R,3'R (R), and mixture (M) AST were evaluated in chemical-based assays, cellular antioxidant assays (CAA), and an organism-based model. S AST exhibited the strongest activity in chemical assays and CAA. The median lifespan of Caenorhabditis elegans fed with S, R and M AST was found to increase by 27.61%, 25.25% and 22.69%, respectively. The three stereoisomeric AST did not cause adverse effects on the physiological functions of C. elegans. A decreasing trend of intracellular ROS accumulation caused by AST treatment was accompanied by the prolonged lifespan. Our results provided mechanistic information on the antioxidation and anti ageing activities of different stereoisomeric AST, which is useful for rational utilization of AST in functional food. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：50 / 61

页数：12

共 57 条

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