Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma

被引:328
作者
Baugh, Christine M. [1 ]
Stamm, Julie M. [1 ]
Riley, David O. [1 ]
Gavett, Brandon E. [2 ]
Shenton, Martha E. [3 ]
Lin, Alexander [4 ]
Nowinski, Christopher J. [1 ,5 ]
Cantu, Robert C. [1 ,5 ,6 ,7 ]
McKee, Ann C. [1 ,8 ,9 ,10 ]
Stern, Robert A. [1 ,6 ,8 ,10 ]
机构
[1] Boston Univ, Sch Med, Ctr Study Traumat Encephalopathy, Boston, MA 02118 USA
[2] Univ Colorado, Dept Psychol, Colorado Springs, CO 80933 USA
[3] Harvard Univ, Brigham & Womens Hosp, Psychiat Neuroimaging Lab, Dept Psychiat,Sch Med, Boston, MA 02115 USA
[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Clin Spect, Boston, MA 02115 USA
[5] Sports Legacy Inst, Waltham, MA USA
[6] Boston Univ, Sch Med, Dept Neurosurg, Boston, MA 02118 USA
[7] Emerson Hosp, Neurosurg Serv, Dept Surg & Sports Med, Concord, MA USA
[8] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
[9] Boston Univ, Sch Med, Dept Pathol, Boston, MA 02118 USA
[10] Boston Univ, Sch Med, Alzheimers Dis Ctr, Boston, MA 02118 USA
基金
美国国家卫生研究院;
关键词
Chronic traumatic encephalopathy; Traumatic brain injury; Dementia; Concussion; Tauopathy; Dementia pugilistica; ALZHEIMERS ASSOCIATION WORKGROUPS; MAGNETIC-RESONANCE SPECTROSCOPY; FOOTBALL-LEAGUE PLAYER; HEAD-INJURY; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; PREDICTIVE-VALUE; AXONAL INJURY; PUNCH-DRUNK; DISEASE;
D O I
10.1007/s11682-012-9164-5
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries. It is thought to result in executive dysfunction, memory impairment, depression and suicidality, apathy, poor impulse control, and eventually dementia. Beyond repetitive brain trauma, the risk factors for CTE remain unknown. CTE is neuropathologically characterized by aggregation and accumulation of hyperphosphorylated tau and TDP-43. Recent postmortem findings indicate that CTE may affect a broader population than was initially conceptualized, particularly contact sport athletes and those with a history of military combat. Given the large population that could potentially be affected, CTE may represent an important issue in public health. Although there has been greater public awareness brought to the condition in recent years, there are still many research questions that remain. Thus far, CTE can only be diagnosed post-mortem. Current research efforts are focused on the creation of clinical diagnostic criteria, finding objective biomarkers for CTE, and understanding the additional risk factors and underlying mechanism that causes the disease. This review examines research to date and suggests future directions worthy of exploration.
引用
收藏
页码:244 / 254
页数:11
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