Catalytic asymmetric hydrogenation of β-substituted α,β,γ,δ-unsaturated amino acids

被引：39

作者：

Burk, MJ ^{[1
]}

Bedingfield, KM ^{[1
]}

Kiesman, WF ^{[1
]}

Allen, JG ^{[1
]}

机构：

[1] Duke Univ, Dept Chem, Paul M Gross Chem Lab, Durham, NC 27706 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 16期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)00437-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Rh-DuPHOS and Rh-BPE catalyzed hydrogenation of beta-substituted alpha,beta,gamma,delta-unsaturated amino acids establishes two contiguous stereogenic centers simultaneously. Both high regioselectivity and good to excellent enantioselectivity have been demonstrated in this process leading to beta-branched allyl glycine derivatives. Enamide geometry was found to influence stereoselectivity. Studies aimed at defining the scope and limitations of this process are described. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3093 / 3096

页数：4

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