A convenient cross-coupling route to alpha,beta,gamma,delta-unsaturated amino acids

被引：31

作者：

Burk, MJ

Allen, JG

Kiesman, WF

Stoffan, KM

机构：

[1] Paul M. Gross Chemical Laboratory, Department of Chemistry, Duke University, Durham

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(97)00065-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Bromoenamide esters are coupled stereospecifically to vinylboronic acids via a palladium-catalyzed Suzuki reaction. This cross-coupling proceeds under mild conditions with Pd(OAc)(2) in 95% EtOH at 50 degrees C and produces amino acids with 1,3-diene side chains in high yields. (C) 1997 Elsevier Science Ltd.

引用

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页码：1309 / 1312

页数：4

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