In vitro enzymatic degradation kinetics of polymeric blends of crosslinked starch and carboxymethyl cellulose

被引:51
作者
Bajpai, AK [1 ]
Shrivastava, J [1 ]
机构
[1] Govt Autonomous Sci Coll, Dept Chem, Bose Mem Res Lab, Jabalpur 482001, India
关键词
starch; blend; alpha-amylase; degradation; kinetics;
D O I
10.1002/pi.1878
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Hydrophilic blend matrices of crosslinked starch and carboxymethyl cellulose were synthesized and their susceptibilities to enzymatic degradation were assessed by taking alpha-amylase as a model enzyme. The polymeric blends were characterized by FT-IR spectroscopy, differential scanning calorimetry and scanning electron microscopy. The influence of the chemical compositions of the blends, and the pH values and temperatures of the alpha-amylase solutions was investigated by studying the swelling and degradation kinetics of the blends. The impact of the concentrations of the enzyme solutions on the degradation profiles was also examined. The blends were found to exhibit a mixed type of degradation mechanism, ie both diffusion and surface erosion. (c) 2005 Society of Chemical Industry.
引用
收藏
页码:1524 / 1536
页数:13
相关论文
共 47 条
[1]   PHYSICOCHEMICAL ASPECTS OF DRUG RELEASE .10. INVESTIGATION OF THE APPLICABILITY OF THE CUBE ROOT LAW FOR CHARACTERIZATION OF THE DISSOLUTION RATE OF FINE PARTICULATE MATERIALS [J].
ANDERBERG, EK ;
NYSTROM, C .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1990, 62 (2-3) :143-151
[2]   In vitro assessment of the enzymatic degradation of several starch based biomaterials [J].
Azevedo, HS ;
Gama, FM ;
Reis, RL .
BIOMACROMOLECULES, 2003, 4 (06) :1703-1712
[3]   α-Amylase induced enhanced enzymatic degradation of binary polymeric blends of crosslinked starch and gelatin [J].
Bajpai, AK ;
Shrivastava, J .
JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY, 2004, A41 (08) :949-969
[4]   Immobilization of α-amylase in vinyl-polymer-based interpenetrating polymer networks [J].
Bajpai, AK ;
Bhanu, S .
COLLOID AND POLYMER SCIENCE, 2003, 282 (01) :76-83
[5]   Enhanced water sorption of a semi-interpenetrating polymer network (IPN) of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(ethylene glycol) (PEG) [J].
Bajpai, AK ;
Shrivastava, M .
JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY, 2002, 39 (07) :667-692
[6]  
Bajpai AK, 2001, REACT FUNCT POLYM, V50, P9
[7]   Starch-chitosan hydrogels prepared by reductive alkylation cross-linking [J].
Baran, ET ;
Mano, JF ;
Reis, RL .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2004, 15 (07) :759-765
[8]   Surface characterization of flax, hemp and cellulose fibers; Surface properties and the water uptake behavior [J].
Bismarck, A ;
Aranberri-Askargorta, I ;
Springer, J ;
Lampke, T ;
Wielage, B ;
Stamboulis, A ;
Shenderovich, I ;
Limbach, HH .
POLYMER COMPOSITES, 2002, 23 (05) :872-894
[9]   An original kinetic model for the enzymatic hydrolysis of starch during mashing [J].
Brandam, C ;
Meyer, XM ;
Proth, J ;
Strehaiano, P ;
Pingaud, H .
BIOCHEMICAL ENGINEERING JOURNAL, 2003, 13 (01) :43-52
[10]   Preparation and characterisation of composites based on biodegradable polymers for "in vivo" application [J].
Calandrelli, L ;
Immirzi, B ;
Malinconico, M ;
Volpe, MG ;
Oliva, A ;
Della Ragione, F .
POLYMER, 2000, 41 (22) :8027-8033