Typhoid fever: pathogenesis and disease

被引：126

作者：

House, D ^{[1
]}

Bishop, A ^{[1
]}

Parry, C ^{[1
]}

Dougan, G ^{[1
]}

Wain, J ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, London W7 2AZ, England

来源：

CURRENT OPINION IN INFECTIOUS DISEASES | 2001年 / 14卷 / 05期

关键词：

D O I：

10.1097/00001432-200110000-00011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Typhoid fever is an infectious disease of global distribution. Although there is a wealth of data on Salmonella typhimurium infection in the mouse and the interaction of this serovar with human cell lines in vitro, there is a relatively small amount of data on S. typhi and the pathogenesis of typhoid fever. In this review we focus on three areas: adherence to and invasion of gut epithelial cells, dissemination to systemic sites, and survival and replication within host cells. In addition, we attempt to put current salmonella research into the context of typhoid fever. Curr Opin Infect Dis 14:573-578. (C), 2001 Lippincott Williams & Wilkins.

引用

页码：573 / 578

页数：6

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