Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

被引：214

作者：

Kim, CA ^{[1
]}

Phillips, ML ^{[1
]}

Kim, W ^{[1
]}

Gingery, M ^{[1
]}

Tran, HH ^{[1
]}

Robinson, MA ^{[1
]}

Faham, S ^{[1
]}

Bowie, JU ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Biochem & Chem, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90024 USA

来源：

EMBO JOURNAL | 2001年 / 20卷 / 15期

关键词：

chromatin silencing; leukemia; oncogene; Pointed domain; polycomb group proteins;

D O I：

10.1093/emboj/20.15.4173

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.

引用

页码：4173 / 4182

页数：10

共 54 条

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