The selector gene cut represses a neural cell fate that is specified independently of the Achaete-Scute-Complex and atonal

被引：18

作者：

Brewster, R ^{[1
]}

Hardiman, K ^{[1
]}

Deo, M ^{[1
]}

Khan, S ^{[1
]}

Bodmer, R ^{[1
]}

机构：

[1] Univ Michigan, Dept Biol, Ann Arbor, MI 48109 USA

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 105卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

neurogenesis; homeobox; proneural genes; neurogenic genes; peripheral nervous system; Drosophila; development; engrailed; pdm; lineage; cell fate specification; type II neurons; multiple dendritic neurons;

D O I：

10.1016/S0925-4773(01)00375-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The peripheral nervous system (PNS) of Drosophila offers a powerful system to precisely identify individual cells and dissect their genetic pathways of development. The mode of specification of a subset of larval PNS cells, the multiple dendritic (md) neurons (or type II neurons), is complex and still poorly understood. Within the dorsal thoracic and abdominal segments, two md neurons, dbd and dda1, apparently require the proneural gene amos but not atonal (ato) or Achaete-Scute-Complex (ASC) genes. ASC normally acts via the neural selector gene cut to specify appropriate sensory organ identities. Here, we show that dbd- and dda1-type differentiation is suppressed by cut in dorsal ASC-dependent md neurons. Thus, cut is not only required to promote an ASC-dependent mode of differentiation, but also represses an ASC- and are-independent fate that leads to dbd and dda1 differentiation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：57 / 68

页数：12

共 85 条

[11] A LATE ROLE FOR A SUBSET OF NEUROGENIC GENES TO LIMIT SENSORY PRECURSOR RECRUITMENTS IN DROSOPHILA EMBRYOS [J].