Diclofenac sodium delivery to the eye:: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct

被引：158

作者：

Attama, Anthony A. ^{[1
,2
]}

Reichl, Stephan ^{[2
]}

Mueller-Goymann, Christel C. ^{[2
]}

机构：

[1] Univ Nigeria, Dept Pharmaceut, Nsukka 410001, Enugu State, Nigeria

[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Pharmazeut Technol, D-38106 Braunschweig, Germany

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2008年 / 355卷 / 1-2期

关键词：

diclofenac sodium; solid lipid nanoparticles; surface modification; human cornea construct; drug permeation; ocular drug delivery;

D O I：

10.1016/j.ijpharm.2007.12.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Solid lipid nanoparticles (SLNs) were prepared with a combination of homolipid from goat (goat fat) and phospholipid, and evaluated for diclofenac sodium (DNa) delivery to the eye using bio-engineered human cornea, produced from immortalized human corneal endothelial cells (HENC), stromal fibroblasts and epithelial cells CEPI 17 CL 4. Encapsulation efficiency was high and sustained release of DNa and high permeation through the bio-engineered cornea were achieved. Results obtained in this work showed that permeation of DNa through the cornea construct was improved by formulation as SLN modified with phospholipid. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：307 / 313

页数：7