The origins of forgetting in a case of isolated retrograde amnesia following a haemorrhage: Evidence from functional imaging

被引:30
作者
Costello, A
Fletcher, PC
Dolan, RJ
Frith, CD
Shallice, T
机构
[1] Neuropsychol Unit, London SE5 8AL, England
[2] Inst Neurol, Wellcome Dept Cognit Neurol, London WC1N 3BG, England
[3] Univ London Univ Coll, Inst Cognit Neurosci, London WC1E 6BT, England
[4] SISSA, I-34014 Trieste, Italy
[5] Royal Free Hosp, Sch Med, Acad Dept Psychiat, London NW3, England
关键词
D O I
10.1080/13554799808410637
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Following a left superior dorsolateral prefrontal haemorrhage, a man in his 40s presented with a dense isolated retrograde amnesia for 19 years preceding the stroke. This period of his life contained many highly stressful situations. Functional neuroimaging using PET was carried out while he attempted to recall events using family snapshots as stimuli. There were three conditions - those where the stimuli related to the amnesic period and in which he had been present at the event (amnesic-present condition), analogous events from outside that period (non-amnesic present condition) and events where he was not present (not-present condition). Activation in the amnesic-present condition differed significantly from the other two conditions in three cortical regions. Activation was greater in part of the precuneus, but less in both the right posterior ventrolateral frontal cortex and in a region close to the lesion. We argue that an explanation in terms of malingering can be rejected and instead propose that this deficit can be explained by the fact that the recursive self-cueing of memory traces characteristic of autobiographical retrieval was not properly triggered.
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页码:437 / 446
页数:10
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