Heparin-induced thrombocytopenia

被引：14

作者：

Kaplan, KL ^{[1
]}

Francis, CW ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Vasc Med Unit, Rochester, NY 14642 USA

来源：

BLOOD REVIEWS | 1999年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0268-960X(99)90018-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin-induced thrombocytopenia with or without thrombosis has been recognized increasingly as a serious complication of heparin use. This article reviews type II heparin-induced thrombocytopenia, which is mediated by an antibody that in most cases has specificity for a complex between heparin and platelet factor 4, a secreted platelet alpha-granule protein. The antibody-heparin-platelet factor 4 complex can activate platelets and endothelial cells, thereby initiating thrombosis. Clinical thrombosis in this syndrome may be arterial or venous. Treatment of the syndrome requires discontinuation of heparin and institution of an alternative anticoagulant.

引用

页码：1 / 7

页数：7

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