Jun: Stealth, stability, and transformation

被引：10

作者：

Vogt, PK ^{[1
]}

Bader, AG ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

MOLECULAR CELL | 2005年 / 19卷 / 04期

关键词：

D O I：

10.1016/j.molcel.2005.08.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent paper by We! and collaborators in Cancer Cell sheds light on the effects of one of the mutations in v-Jun and has broad implications for our understanding of control mechanisms that direct the timing of important cell cycle functions (Wei et al., 2005).

引用

页码：432 / 433

页数：2

共 10 条

[1] c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors [J].

Fuchs, SY ;

Xie, B ;

Adler, V ;

Fried, VA ;

Davis, RJ ;

Ronai, Z .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) :32163-32168

[2] Skp2 inhibits FOX01 in tumor suppression through ubiquitin-mediated degradation [J].

Huang, H ;

Regan, KM ;

Wang, F ;

Wang, DP ;

Smith, DI ;

van Deursen, JMA ;

Tindall, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (05) :1649-1654

[3] Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases [J].

Musti, AM ;

Treier, M ;

Bohmann, D .

SCIENCE, 1997, 275 (5298) :400-402

[4] The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling [J].

Nateri, AS ;

Riera-Sans, L ;

Da Costa, C ;

Behrens, A .

SCIENCE, 2004, 303 (5662) :1374-1378

[5] Oncogenic effect of delta deletion in v-Jun does not result from uncoupling Jun from JNK signaling [J].

Sprowles, A ;

Wisdom, R .

ONCOGENE, 2003, 22 (04) :498-506

[6] The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase [J].

Wei, WY ;

Jin, JP ;

Schlisio, S ;

Harper, JW ;

Kaelin, WG .

CANCER CELL, 2005, 8 (01) :25-33

[7] JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun [J].

Weiss, C ;

Schneider, S ;

Wagner, EF ;

Zhang, XH ;

Seto, E ;

Bohmann, D .

EMBO JOURNAL, 2003, 22 (14) :3686-3695

[8]

Weiss C, 2004, CELL CYCLE, V3, P111

[9] The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation [J].

Welcker, M ;

Orian, A ;

Jin, JP ;

Grim, JA ;

Harper, JW ;

Eisenman, RN ;

Clurman, BE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (24) :9085-9090

[10] Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation [J].

Welcker, M ;

Singer, J ;

Loeb, KR ;

Grim, J ;

Bloecher, A ;

Gurien-West, M ;

Clurman, BE ;

Roberts, JM .

MOLECULAR CELL, 2003, 12 (02) :381-392

← 1 →