Localization of mRNA for Dri 42, subtype 2b of phosphatidic acid phosphatase, in the rat brain during development

被引：5

作者：

Suzuki, R

Sakagami, H

Owada, Y

Handa, Y

Kondo, H ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med Sci, Dept Cell Biol, Div Histol, Sendai, Miyagi 980, Japan

[2] Tohoku Univ, Grad Sch Med Sci, Div Rehabil, Sendai, Miyagi 9808575, Japan

来源：

MOLECULAR BRAIN RESEARCH | 1999年 / 66卷 / 1-2期

关键词：

in situ hybridization; Dri; 42; phosphatidic acid phosphatase; ventricular germinal zone; Bergmann glia;

D O I：

10.1016/S0169-328X(99)00026-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of a gene termed Dri 42, a differentiation-related gene originally identified from intestine and a gene encoding phosphatidic acid phosphatase 2b isoform, was localized in developing and matured rat brains by in situ hybridization histochemical analysis. The gene expression was dominant in the ventricular germinal zone without significant expression in the intermediate, mantle and marginal zones throughout embryonic brain and spinal cord. The dominant expression in the ventricular germinal zone was maintained at PO and P7, but it markedly decreased at later postnatal stages, while persistently high expression was detected in Bergmann glial cells of the cerebellar Purkinje cell layer throughout the postnatal development. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：195 / 199

页数：5

共 19 条

[1] The Dri 42 gene, whose expression is up-regulated during epithelial differentiation, encodes a novel endoplasmic reticulum resident transmembrane protein [J].