Metabolism - Partial leptin deficiency and human adiposity

被引:290
作者
Farooqi, IS
Keogh, JM
Kamath, S
Jones, S
Gibson, WT
Trussell, R
Jebb, SA
Lip, GYH
O'Rahilly, S
机构
[1] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England
[2] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England
[3] City Hosp, Univ Dept Med, Birmingham B18 7QH, W Midlands, England
[4] MRC Human Nutr Res, Cambridge CB1 9NL, England
[5] Alberta Childrens Prov Gen Hosp, Dept Med Genet, Calgary, AB T2T 5C7, Canada
[6] Alberta Childrens Prov Gen Hosp, Dept Paediat Endocrinol, Calgary, AB T2T 5C7, Canada
关键词
D O I
10.1038/35102112
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
[No abstract available]
引用
收藏
页码:34 / 35
页数:2
相关论文
共 9 条
  • [1] Heterozygosity for Lepob or Leprdb affects body composition and leptin homeostasis in adult mice
    Chung, WK
    Belfi, K
    Chua, M
    Wiley, J
    Mackintosh, R
    Nicolson, M
    Boozer, CN
    Leibel, RL
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 274 (04) : R985 - R990
  • [2] BODY-MASS INDEX AS A MEASURE OF BODY FATNESS - AGE-SPECIFIC AND SEX-SPECIFIC PREDICTION FORMULAS
    DEURENBERG, P
    WESTSTRATE, JA
    SEIDELL, JC
    [J]. BRITISH JOURNAL OF NUTRITION, 1991, 65 (02) : 105 - 114
  • [3] Effects of recombinant leptin therapy in a child with congenital leptin deficiency
    Farooqi, IS
    Jebb, SA
    Langmack, G
    Lawrence, E
    Cheetham, CH
    Prentice, AM
    Hughes, IA
    McCamish, MA
    O'Rahilly, S
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (12) : 879 - 884
  • [4] What's in a name? In search of leptin's physiologic role
    Flier, JS
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (05) : 1407 - 1413
  • [5] Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance
    Havel, PJ
    [J]. PROCEEDINGS OF THE NUTRITION SOCIETY, 2000, 59 (03) : 359 - 371
  • [6] Recombinant leptin for weight loss in obese and lean adults - A randomized, controlled, dose-escalation trial
    Heymsfield, SB
    Greenberg, AS
    Fujioka, K
    Dixon, RM
    Kushner, R
    Hunt, T
    Lubina, JA
    Patane, J
    Self, B
    Hunt, P
    McCamish, M
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (16): : 1568 - 1575
  • [7] Congenital leptin deficiency is associated with severe early-onset obesity in humans
    Montague, CT
    Farooqi, IS
    Whitehead, JP
    Soos, MA
    Rau, H
    Wareham, NJ
    Sewter, CP
    Digby, JE
    Mohammed, SN
    Hurst, JA
    Cheetham, CH
    Earley, AR
    Barnett, AH
    Prins, JB
    ORahilly, S
    [J]. NATURE, 1997, 387 (6636) : 903 - 908
  • [8] Relatively low plasma leptin concentrations precede weight gain in Pima Indians
    Ravussin, E
    Pratley, RE
    Maffei, M
    Wang, H
    Friedman, JM
    Bennett, PH
    Bogardus, C
    [J]. NATURE MEDICINE, 1997, 3 (02) : 238 - 240
  • [9] POSITIONAL CLONING OF THE MOUSE OBESE GENE AND ITS HUMAN HOMOLOG
    ZHANG, YY
    PROENCA, R
    MAFFEI, M
    BARONE, M
    LEOPOLD, L
    FRIEDMAN, JM
    [J]. NATURE, 1994, 372 (6505) : 425 - 432