Chiral hydroxythiols as catalysts for enantioselective borane ketone reductions

被引：17

作者：

Fiaud, JC ^{[1
]}

Mazé, F ^{[1
]}

Kagan, HB ^{[1
]}

机构：

[1] Univ Paris Sud, ICMO, Lab React Organ Select, F-91405 Orsay, France

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 20期

关键词：

D O I：

10.1016/S0957-4166(98)00376-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Several chiral 1,2- and 1,3-hydroxythiols derived from (R)-camphor, (1S)-(+)-10-camphorsulfonyl chloride, cysteine and cystine derivatives were prepared and evaluated as catalysts in borane ketone reductions. Under the best experimental conditions (10 mol% catalyst, THF, 35 degrees C), a 95% yield of (R)-1-phenylethanol of 64% ee was obtained in the borane reduction of acetophenone. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3647 / 3655

页数：9

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