The evolving role of sirolimus in renal transplantation

被引:17
作者
Dupont, P [1 ]
Warrens, AN [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Div Med, London, England
关键词
D O I
10.1093/qjmed/hcg072
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In summary, sirolimus is an exciting addition to our immunosuppressive armamentarium. There are encouraging early data suggesting that this drug may have significant advantages over existing agents, namely the promotion of tolerance, reduction in chronic allograft vasculopathy and avoidance of toxic effects of other immunosuppressive drugs. If further large clinical studies can confirm its safety and efficacy over a longer duration of follow-up this will no doubt promote its more widespread adoption.
引用
收藏
页码:401 / 409
页数:9
相关论文
共 65 条
  • [21] Ig receptor binding protein 1 (α4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A
    Inui, S
    Sanjo, H
    Maeda, K
    Yamamoto, H
    Miyamoto, E
    Sakaguchi, N
    [J]. BLOOD, 1998, 92 (02) : 539 - 546
  • [22] BCR signal through α4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation
    Inui, S
    Maeda, K
    Hua, DR
    Yamashita, T
    Yamamoto, H
    Miyamoto, E
    Aizawa, S
    Sakaguchi, N
    [J]. INTERNATIONAL IMMUNOLOGY, 2002, 14 (02) : 177 - 187
  • [23] Drug eluting coronary stents - May sound the death knell for restenosis
    Jenkins, NP
    Prendergast, BD
    Thomas, M
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2002, 325 (7376): : 1315 - 1316
  • [24] PRECLINICAL EVALUATION OF A NEW POTENT IMMUNOSUPPRESSIVE AGENT, RAPAMYCIN
    KAHAN, BD
    CHANG, JY
    SEHGAL, SN
    [J]. TRANSPLANTATION, 1991, 52 (02) : 185 - 191
  • [25] Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in Caucasian recipients of mismatched primary renal allografts: A phase II trial
    Kahan, BD
    Julian, BA
    Pescovitz, MD
    Vanrenterghem, Y
    Neylan, J
    [J]. TRANSPLANTATION, 1999, 68 (10) : 1526 - 1532
  • [26] Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantation
    Kahan, BD
    Podbielski, J
    Napoli, KL
    Katz, SM
    Meier-Kriesche, HU
    Van Buren, CT
    [J]. TRANSPLANTATION, 1998, 66 (08) : 1040 - 1046
  • [27] Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study
    Kahan, BD
    [J]. LANCET, 2000, 356 (9225) : 194 - 202
  • [28] KAY JE, 1991, IMMUNOLOGY, V72, P544
  • [29] KNIGHT R, 1993, TRANSPLANTATION, V55, P947
  • [30] Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients
    Kreis, H
    Cisterne, JM
    Land, W
    Wramner, L
    Squifflet, JP
    Abramowicz, D
    Campistol, JM
    Morales, JM
    Grinyo, JM
    Mourad, G
    Berthoux, FC
    Brattström, C
    Lebranchu, Y
    Vialtel, P
    [J]. TRANSPLANTATION, 2000, 69 (07) : 1252 - 1260