The high valent nonheme Fe2O2 diamond core:: Comparisons with the heme ferryl

被引：8

作者：

Que, L

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Ctr Met Biocatalysis, Minneapolis, MN 55455 USA

来源：

PURE AND APPLIED CHEMISTRY | 1998年 / 70卷 / 04期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1351/pac199870040947

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A high-valent Fe2O2 diamond core structure is proposed as the key oxidizing species in the oxygen activation chemistry of nonheme diiron enzymes such as methane monooxygenase, ribonucleotide reductase, and fatty acid desaturases. Synthetic precedents serve as the basis for this hypothesis, which is consistent with recent EXAFS results on the high-valent intermediate of methane monooxygenase. The structural and reactivity features of this core are compared with those of the heme ferryl, the key oxidizing species in heme enzymes.

引用

收藏

页码：947 / 954

页数：8

相关论文

共 39 条

[1]

ABERG A, 1993, BIOCHEMISTRY-US, V32, P9845

[2]

ATTA M, 1992, J BIOL CHEM, V267, P20682

[3] MECHANISM OF ASSEMBLY OF THE TYROSYL RADICAL DINUCLEAR IRON CLUSTER COFACTOR OF RIBONUCLEOTIDE REDUCTASE [J].

BOLLINGER, JM ;

EDMONDSON, DE ;

HUYNH, BH ;

FILLEY, J ;

NORTON, JR ;

STUBBE, J .

SCIENCE, 1991, 253 (5017) :292-298

[4] PROBING STRUCTURE-FUNCTION RELATIONS IN HEME-CONTAINING OXYGENASES AND PEROXIDASES [J].

DAWSON, JH .

SCIENCE, 1988, 240 (4851) :433-439

[5] MOSSBAUER AND ELECTRON-PARAMAGNETIC RESONANCE STUDY OF THE DOUBLE-EXCHANGE AND HEISENBERG-EXCHANGE INTERACTIONS IN A NOVEL BINUCLEAR FE(II/III) DELOCALIZED-VALENCE COMPOUND [J].

DING, XQ ;

BOMINAAR, EL ;

BILL, E ;

WINKLER, H ;

TRAUTWEIN, AX ;

DRUEKE, S ;

CHAUDHURI, P ;

WIEGHARDT, K .

JOURNAL OF CHEMICAL PHYSICS, 1990, 92 (01) :178-186

[6] A HIGH-VALENT NONHEME IRON INTERMEDIATE - STRUCTURE AND PROPERTIES OF [FE-2(MU-O)(2)(5-ME-TPA)(2)](CLO4)(3) [J].

DONG, YH ;

FUJII, H ;

HENDRICH, MP ;

LEISING, RA ;

PAN, GF ;

RANDALL, CR ;

WILKINSON, EC ;

ZANG, Y ;

QUE, L ;

FOX, BG ;

KAUFFMANN, K ;

MUNCK, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (10) :2778-2792

[7] AN EXCHANGE-COUPLED COMPLEX WITH LOCALIZED HIGH-SPIN FE-IV AND FE-III SITES OF RELEVANCE TO CLUSTER-X OF ESCHERICHIA-COLI RIBONUCLEOTIDE REDUCTASE [J].

DONG, YH ;

QUE, L ;

KAUFFMANN, K ;

MUNCK, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (45) :11377-11378

[8]

Elango N, 1997, PROTEIN SCI, V6, P556

[9] REACTIONS OF NONHEME IRON(II) CENTERS WITH DIOXYGEN IN BIOLOGY AND CHEMISTRY [J].

FEIG, AL ;

LIPPARD, SJ .

CHEMICAL REVIEWS, 1994, 94 (03) :759-805

[10] Excited-state contributions to ground-state properties of mixed-valence dimers: Spectral and electronic-structural studies of [Fe-2(OH)(3)(tmtacn)(2)](2+) related to the [Fe2S2](+) active sites of plant-type ferredoxins [J].

Gamelin, DR ;

Bominaar, EL ;

Kirk, ML ;

Wieghardt, K ;

Solomon, EI .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (34) :8085-8097

← 1 2 3 4 →