The high valent nonheme Fe2O2 diamond core:: Comparisons with the heme ferryl

被引:8
作者
Que, L
机构
[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Ctr Met Biocatalysis, Minneapolis, MN 55455 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
D O I
10.1351/pac199870040947
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A high-valent Fe2O2 diamond core structure is proposed as the key oxidizing species in the oxygen activation chemistry of nonheme diiron enzymes such as methane monooxygenase, ribonucleotide reductase, and fatty acid desaturases. Synthetic precedents serve as the basis for this hypothesis, which is consistent with recent EXAFS results on the high-valent intermediate of methane monooxygenase. The structural and reactivity features of this core are compared with those of the heme ferryl, the key oxidizing species in heme enzymes.
引用
收藏
页码:947 / 954
页数:8
相关论文
共 39 条
[21]   HIGH-VALENT OXOMANGANESE CLUSTERS - STRUCTURAL AND MECHANISTIC WORK RELEVANT TO THE OXYGEN-EVOLVING CENTER IN PHOTOSYSTEM-II [J].
MANCHANDA, R ;
BRUDVIG, GW ;
CRABTREE, RH .
COORDINATION CHEMISTRY REVIEWS, 1995, 144 :1-38
[22]  
MCMURRY TJ, 1986, CYTOCHROME P, V450, P1
[23]   STRUCTURE AND FUNCTION OF THE ESCHERICHIA-COLI RIBONUCLEOTIDE REDUCTASE PROTEIN R2 [J].
NORDLUND, P ;
EKLUND, H .
JOURNAL OF MOLECULAR BIOLOGY, 1993, 232 (01) :123-164
[24]   SYNTHESIS, STRUCTURE, AND PROPERTIES OF A COMPLEX THAT CONSISTS OF AN(MN2O2(O2CCH3)]2+ CORE AND A SPANNING HEXADENTATE LIGAND [J].
PAL, S ;
GOHDES, JW ;
WILISCH, WCA ;
ARMSTRONG, WH .
INORGANIC CHEMISTRY, 1992, 31 (04) :713-716
[25]   STRUCTURAL CHARACTERIZATION OF HORSERADISH-PEROXIDASE USING EXAFS SPECTROSCOPY - EVIDENCE FOR FE=O LIGATION IN COMPOUND-I AND COMPOUND-II [J].
PENNERHAHN, JE ;
EBLE, KS ;
MCMURRY, TJ ;
RENNER, M ;
BALCH, AL ;
GROVES, JT ;
DAWSON, JH ;
HODGSON, KO .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (24) :7819-7825
[26]   Recombinant toluene-4-monooxygenase: Catalytic and Mossbauer studies of the purified diiron and Rieske components of a four-protein complex [J].
Pikus, JD ;
Studts, JM ;
Achim, C ;
Kauffmann, KE ;
Munck, E ;
Steffan, RJ ;
McClay, K ;
Fox, BG .
BIOCHEMISTRY, 1996, 35 (28) :9106-9119
[27]  
Que Jr L., 1993, BIOINORGANIC CATALYS, P347
[28]   OXYGEN ACTIVATION AT THE DIIRON CENTER OF RIBONUCLEOTIDE REDUCTASE [J].
QUE, L .
SCIENCE, 1991, 253 (5017) :273-274
[29]   MECHANISM OF ASSEMBLY OF THE TYROSYL RADICAL-DIIRON(III) COFACTOR OF ESCHERICHIA-COLI RIBONUCLEOTIDE REDUCTASE .1. MOSSBAUER CHARACTERIZATION OF THE DIFERRIC RADICAL PRECURSOR [J].
RAVI, N ;
BOLLINGER, JM ;
HUYNH, BH ;
EDMONDSON, DE ;
STUBBE, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (18) :8007-8014
[30]  
ROSENZWEIG AC, 1993, NATURE, V366, P537, DOI 10.1038/366537a0