Cerebral postischemic hypoperfusion is mediated by ET(A) receptors

被引：31

作者：

Spatz, M

Yasuma, Y

Strasser, A

McCarron, RM

机构：

[1] Stroke Branch, NINDS, National Institutes of Health, Bethesda, MD 20892-4128

来源：

BRAIN RESEARCH | 1996年 / 726卷 / 1-2期

关键词：

endothelin; nitric oxide; cerebral ischemia; cerebral blood flow; endothelin(A) receptor;

D O I：

10.1016/0006-8993(96)00409-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effect of ET(A)-receptor antagonist, BQ123, on postischemic hypoperfusion in the presence or absence of nitric oxide synthetase inhibitor, N omega-nitro-L-arginine (NLA), was investigated in Mongolian gerbils. BQ123 given prior to ischemia reversed the early incomplete recovery of cerebral blood flow observed with NLA without affecting the late postischemic hypoperfusion. Additional postischemic administration of BQ123 also reversed (P < 0.01) the late postischemic hypoperfusion seen in NLA-, N omega-nitro-D-arginine methyl ester- or Ringer's-treated animals.

引用

页码：242 / 246

页数：5