Glancing behind virus load variation in HIV-1 infection

被引：47

作者：

Bonhoeffer, S ^{[1
]}

Funk, GA

Günthard, HF

Fischer, M

Müller, V

机构：

[1] ETH, ETH Zentrum NW, CH-8092 Zurich, Switzerland

[2] Univ Zurich Hosp, Div Infect Dis, CH-8091 Zurich, Switzerland

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 11期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/j.tim.2003.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the steady-state virus load during HIV-1 infection is remarkably stable within a patient, it displays variation over several orders of magnitude between patients. Despite intensive research, the host and virus factors that are responsible for the observed variation remain poorly understood. Comparison of model predictions with clinical data suggests that most of the variation in steady-state virus load between patients reflects variation of the net rate at which activated CD4 cells are produced.

引用

页码：499 / 504

页数：6

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