Highly stereoselective preparation of 3,3-disubstituted acrylates on polyethylene glycol

被引：25

作者：

Blettner, CG

König, WA

Stenzel, W

Schotten, T

机构：

[1] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany

[2] Lilly Forsch GmbH, D-20253 Hamburg, Germany

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 11期

关键词：

stereoselection; polymer support; Heck reactions; Wadsworth-Emmons reactions;

D O I：

10.1016/S0040-4039(99)00157-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly stereoselective preparation of sterically hindered (E) and (Z)-3,3-diaryl acrylic acid esters using a parallel synthesis approach is described. The liquid phase reaction utilises polyethylene glycol monomethyl ether 5000 (mPEG 5000) as a soluble polymeric support and phase-transfer agent. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2101 / 2102

页数：2

共 10 条

[1] HORNER-WADSWORTH-EMMONS REACTION - USE OF LITHIUM-CHLORIDE AND AN AMINE FOR BASE SENSITIVE COMPOUNDS [J].