Mouse cytokine profiles associated with Brucella abortus RB51 vaccination or B-abortus 2308 infection

被引：47

作者：

Pasquali, P

Adone, R

Gasbarre, LC

Pistoia, C

Ciuchini, F

机构：

[1] Ist Super Sanita, Lab Vet Med, I-00161 Rome, Italy

[2] ARS, Immunol & Dis Resistance Lab, Anim & Nat Resources Inst, USDA, Beltsville, MD 20705 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 10期

关键词：

D O I：

10.1128/IAI.69.10.6541-6544.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study indicated that mice immunized with Brucella abortus RB51 bacteria and subsequently challenged with B. abortus 2308 were protected from reinfection. After vaccination, both Th1 and Th2 cytokine patterns were observed, Of those, the early production of gamma interferon seems to have the prominent role in inducing an immunologically based protection.

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页码：6541 / 6544

页数：4

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