Skeletal stem cells

被引：292

作者：

Bianco, Paolo ^{[1
]}

Robey, Pamela G. ^{[2
]}

机构：

[1] Univ Roma La Sapienza, Dept Mol Med, I-00161 Rome, Italy

[2] Natl Inst Dent & Craniofacial Res, Craniofacial & Skeletal Dis Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

DEVELOPMENT | 2015年 / 142卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Bone marrow stromal cell; Bone; Cartilage; Hematopoiesis; In vivo transplantation; Skeletal stem cells; BONE-MARROW; IN-VITRO; MESENCHYMAL PROGENITORS; ALKALINE-PHOSPHATASE; OSTEOGENIC CELLS; DIFFERENTIATION; CARTILAGE; RECEPTOR; VIVO; TRANSPLANTATION;

D O I：

10.1242/dev.102210

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow organ. SSCs conjoin skeletal and hematopoietic physiology, and are a tool for understanding and ameliorating skeletal and hematopoietic disorders. Here and in the accompanying poster, we concisely discuss the biology of SSCs in the context of the development and postnatal physiology of skeletal lineages, to which their use in medicine must remain anchored.

引用

页码：1023 / 1027

页数：5

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