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Unraveling V(D)J recombination: Insights into gene regulation

被引：269
作者：
Jung, D [1 ]
Alt, FW [1 ]
机构：
[1] Harvard Univ, Howard Hughes Med Inst, Childrens Hosp, CBR Inst Biomed Res Inc,Med Sch, Boston, MA 02115 USA
来源：
CELL | 2004年 / 116卷 / 02期
关键词：
D O I：
10.1016/S0092-8674(04)00039-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports-the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.
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页码：299 / 311
页数：13
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