The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling

被引：30

作者：

Coulson, EJ ^{[1
]}

Reid, K

Shipham, KM

Morley, S

Kilpatrick, TJ

Bartlett, R

机构：

[1] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[2] Walter & Eliza Inst Med Res, Parkville, Vic, Australia

来源：

NGF AND RELATED MOLECULES IN HEALTH AND DISEASE | 2004年 / 146卷

关键词：

p75 neurotrophin receptor; cell death pathways; K+ channel; neurotransmission; neurotrophin; apoptosome; G-protein coupled receptors;

D O I：

10.1016/S0079-6123(03)46003-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of p75 neurotrophin receptor (p75(NTR)) in mediating cell death is now well charaterized, however, it is only recently that details of the death signaling pathway have become clearer. This review focuses on the importance of the juxtamembrane Chopper domain region of p75(NTR) in this process. Evidence supporting the involvement of K+ efflux, the apoptosome (caspase-9, apoptosis activating factor-1, APAF-1, and Bcl-(xL)), caspase-3, c-jun kinase, and p53 in the p75(NTR) cell death pathway is discussed and regulatory roles for the p75(NTR) ectodomain and death domain are proposed. The role of synaptic activity is also discussed, in particular the importance of neutrotransmitter-activated K+ channels acting as the gatekeepers of cell survival decisions during development and in neurodegenerative conditions.

引用

页码：41 / 62

页数：22

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