Induction of LTD in the adult hippocampus by the synaptic activation of AMPA/kainate and metabotropic glutamate receptors

被引：123

作者：

Kemp, N ^{[1
]}

Bashir, ZI ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Anat, Bristol BS8 1TD, Avon, England

来源：

NEUROPHARMACOLOGY | 1999年 / 38卷 / 04期

基金：

英国惠康基金;

关键词：

long term depression; LTP; synaptic plasticity; mGlu; N-methyl-D-aspartate; AMPA/kainate; D-2-amino-5-phosphonopentanoate; hippocampus;

D O I：

10.1016/S0028-3908(98)00222-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been suggested that the induction of long-term depression (LTD) may be developmentally regulated since LTD can be readily induced by LFS in slices from young but not adult animals. However, we have recently reported that paired pulse low frequency stimulation (PP-LFS) can reliably induce LTD in the CA1 region of adult hippocampal slices. We now describe the role of glutamate receptors in the induction of LTD in adult hippocampus. The induction of LTD was prevented by the combined application of AMPA/kainate and metabotropic glutamate (mGlu) receptor antagonists (CNQX and LY341495). However, LTD was not blocked by the co-application of NMDA and mGlu receptor antagonists nor by the co-application of NMDA and AMPA/kainate receptor antagonists. Taken together, the above results suggest that activation of either AMPA/kainate or mGlu receptors is sufficient to induce LTD. Therefore, these results suggest that PP-LFS can efficiently activate AMPA/kainate and mGlu receptors in order to induce long-lasting synaptic depression in the CAI region of the adult hippocampus in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：495 / 504

页数：10

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