Matrigel: Basement membrane matrix with biological activity

被引：1204

作者：

Kleinman, HK ^{[1
]}

Martin, GR ^{[1
]}

机构：

[1] NIDCR, NIH, Bethesda, MD 20892 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2005年 / 15卷 / 05期

关键词：

basement membrane; extracellular matrix; differentiation; laminin; matrigel;

D O I：

10.1016/j.semcancer.2005.05.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function. An extract of a tumor was found to contain all of the components present in basement and to be very biologically active. This extract, termed Matrigel, Cultrex, or EHS matrix, promotes cell differentiation, and is used to measure the invasive activity of tumor cells. In vivo, it is used for measuring angiogenic inhibitors and stimulators, to improve graft survival, repair damaged tissues, and increase tumor growth. Published by Elsevier Ltd.

引用

页码：378 / 386

页数：9

共 55 条

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