Caveats of caveolin-1 in cancer progression

被引：166

作者：

Burgermeister, Elke ^{[1
]}

Liscovitch, Mordechai ^{[2
]}

Roecken, Christoph ^{[3
]}

Schmid, Roland M. ^{[1
]}

Ebert, Matthias P. A. ^{[1
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Med 2, D-81675 Munich, Germany

[2] Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel

[3] Charite, Dept Pathol, D-13353 Berlin, Germany

来源：

CANCER LETTERS | 2008年 / 268卷 / 02期

关键词：

cancer progression; caveolin; metastasis; angiogenesis; prognosis;

D O I：

10.1016/j.canlet.2008.03.055

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage-and tissue-specific tumor modulator in vivo. Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its re-expression (regain of function) in advanced-stage metastatic and multidrug resistant tumors. This review is focussed on the role of caveolin-1 in metastasis and angiogenesis and its clinical implications as a prognostic marker in cancer progression. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：187 / 201

页数：15

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