Up-regulation of caveolin expression by cytotoxic agents in drug-sensitive cancer cells

被引：40

作者：

Bélanger, MM ^{[1
]}

Roussel, É ^{[1
]}

Couet, J ^{[1
]}

机构：

[1] Univ Laval, Ctr Lecherche Hop Laval, Unite Rech Pneumol, Inst Univ Cardiol & Pneumol, Ste Foy, PQ G1V 4G5, Canada

来源：

ANTI-CANCER DRUGS | 2003年 / 14卷 / 04期

关键词：

caveolae; caveolin; cytotoxic drug; multidrug resistance;

D O I：

10.1097/00001813-200304000-00005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caveolin 1 expression is down-regulated in various cancer cell lines. Interestingly, in several drug-resistant cancer cells, a strong induction of caveolin 1 expression has been reported, suggesting a role for caveolin 1 in the acquisition and/or the maintenance of the multidrug-resistance phenotype. Here, we show, in drug-sensitive lung cancer cells (A549, Calu-6 or NCl-H69), that exposure to cytotoxic drugs (taxol, doxorubicin or etoposide) is sufficient to strongly up-regulate caveolin 1 and 2 protein levels. This up-regulation is sustained even 1 week after drug removal. Our results suggest that caveolin up-regulation is an early cellular response to a cytotoxic stress taking place before drug resistance.

引用

页码：281 / 287

页数：7

共 29 条

[1] Bangma CH, 1999, SEMIN ONCOL, V26, P422
[2] CAAMANO J, 1991, AM J PATHOL, V139, P839
[3] Molecular and cellular biology of caveolae - Paradoxes and plasticities
Couet, J
Li, SW
Okamoto, T
Scherer, PE
Lisanti, MP
[J]. TRENDS IN CARDIOVASCULAR MEDICINE, 1997, 7 (04) : 103 - 110
[4] Identification of peptide and protein ligands for the caveolin-scaffolding domain - Implications for the interaction of caveolin with caveolae-associated proteins
Couet, J
Li, SW
Okamoto, T
Ikezu, T
Lisanti, MP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) : 6525 - 6533
[5] P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries
Demeule, M
Jodoin, J
Gingras, D
Béliveau, R
[J]. FEBS LETTERS, 2000, 466 (2-3): : 219 - 224
[6] Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo - A role for the caveolin-scaffolding domain
Engelman, JA
Chu, C
Lin, A
Jo, H
Ikezu, T
Okamoto, T
Kohtz, DS
Lisanti, MP
[J]. FEBS LETTERS, 1998, 428 (03): : 205 - 211
[7] Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis
Engelman, JA
Lisanti, MP
Scherer, PE
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (48) : 32111 - 32120
[8] p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression - Activation of Ras-MAP kinase and protein kinase A signaling cascades transcriptionally down-regulates caveolin-1 promoter activity
Engelman, JA
Zhang, XL
Razani, B
Pestell, RG
Lisanti, MP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) : 32333 - 32341
[9] Intracellular cholesterol transport in synchronized human skin fibroblasts
Fielding, CJ
Bist, A
Fielding, PE
[J]. BIOCHEMISTRY, 1999, 38 (08) : 2506 - 2513
[10] Targeted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2C12 myoblasts -: Transient activation of p38 mitogen-activated protein kinase is required for induction of caveolin-3 expression and subsequent myotube formation
Galbiati, F
Volonté, D
Engelman, JA
Scherer, PE
Lisanti, MP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) : 30315 - 30321

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