Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E-coli glutamyl-tRNA synthetase

被引：17

作者：

Bernier, S

Dubois, DY

Habegger-Polomat, C

Gagnon, LP

Lapointe, J

Chênevert, R

机构：

[1] Univ Laval, Dept Chim, Fac Sci & Genie, CREFSIP, Quebec City, PQ G1K 7P4, Canada

[2] Univ Laval, Dept Biochim & Microbiol, Fac Sci & Genie, CREFSIP, Quebec City, PQ G1K 7P4, Canada

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2005年 / 20卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

enzyme inhibitor; glutamylsulfamoyladenosine; glutamyl-tRNA synthetase; pyroglutamylsulfamoyl-adenosine;

D O I：

10.1080/14756360400002007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5'-O-[N-(L-glutamyl)-sulfamoyl]adenosine is a potent competitive inhibitor of E. coli glutamyl-tRNA synthetase with respect to glutamic acid (K-i = 2.8 nM) and is the best inhibitor of this enzyme. It is a weaker inhibitor of mammalian glutamyl-tRNA synthetase (K-i = 70 nM). The corresponding 5'-O-[N-(L-pyroglutamyl)-sulfamoyl] adenosine is a weak inhibitor (K-i = 15 muM) of the E. coli enzyme.

引用

收藏

页码：61 / 67

页数：7

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