Unwinding chromatin for development and growth: a few genes at a time

被引：131

作者：

Kwon, Chang Seob

Wagner, Doris ^{[1
]}

机构：

[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[2] Korea Adv Inst Sci & Technol, Dept Sci Biol, Taejon 305701, South Korea

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 08期

关键词：

D O I：

10.1016/j.tig.2007.05.010

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

SWI/SNF chromatin remodeling ATPases control accessibility of the information stored in the genome. However, the in vivo role of these remodelers has remained poorly understood because null mutations in these result in embryonic lethality in most organisms. Recently, the study of conditional mutants in mammals and viable null mutants in plants, combined with genome wide expression studies in mammals, flies and plants, have implicated chromatin remodeling ATPases in the regulation of many developmental pathways in multicellular eukaryotes. In addition, these studies reveal striking functional specificity for chromatin remodeling in individual developmental processes.

引用

收藏

页码：403 / 412

页数：10

相关论文

共 92 条

[1] A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control [J].

Angus-Hill, ML ;

Schlichter, A ;

Roberts, D ;

Erdjument-Bromage, H ;

Tempst, P ;

Cairns, BR .

MOLECULAR CELL, 2001, 7 (04) :741-751

[2] ATP-dependent chromatin remodeling complexes and their role in nuclear receptor-dependent transcription in vivo [J].

Aoyagi, S ;

Trotter, KW ;

Archer, TK .

VITAMINS AND HORMONES, 2005, 70 :281-307

[3] Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the Delta-Notch signal transduction pathway in Drosophila [J].

Armstrong, JA ;

Sperling, AS ;

Deuring, R ;

Manning, L ;

Moseley, SL ;

Papoulas, O ;

Piatek, CI ;

Doe, CQ ;

Tamkun, JW .

GENETICS, 2005, 170 (04) :1761-1774

[4] The Drosophila BRM complex facilitates global transcription by RNA polymerase II [J].

Armstrong, JA ;

Papoulas, O ;

Daubresse, G ;

Sperling, AS ;

Lis, JT ;

Scott, MP ;

Tamkun, JW .

EMBO JOURNAL, 2002, 21 (19) :5245-5254

[5] RETRACTED: Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1 (Retracted article. See vol. 521, pg. 110, 2015) [J].

Beisel, C ;

Imhof, A ;

Greene, J ;

Kremmer, E ;

Sauer, F .

NATURE, 2002, 419 (6909) :857-862

[6] Unique, shared, and redundant roles for the Arabidopsis SWI/SNF chromatin remodeling ATPases BRAHMA and SPLAYED [J].

Bezhani, Staver ;

Winter, Cara ;

Hershman, Steve ;

Wagner, John D. ;

Kennedy, John F. ;

Kwon, Chang Seob ;

Pfluger, Jennifer ;

Su, Yanhui ;

Wagner, Doris .

PLANT CELL, 2007, 19 (02) :403-416

[7] A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes [J].

Bultman, S ;

Gebuhr, T ;

Yee, D ;

La Mantia, C ;

Nicholson, J ;

Gilliam, A ;

Randazzo, F ;

Metzger, D ;

Chambon, P ;

Crabtree, G ;

Magnuson, T .

MOLECULAR CELL, 2000, 6 (06) :1287-1295

[8] Maternal BRG1 regulates zygotic genome activation in the mouse [J].

Bultman, Scott J. ;

Gebuhr, Thomas C. ;

Pan, Hua ;

Svoboda, Petr ;

Schultz, Richard M. ;

Magnuson, Terry .

GENES & DEVELOPMENT, 2006, 20 (13) :1744-1754

[9] A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in β-globin expression and erythroid development [J].

Bultman, SJ ;

Gebuhr, TC ;

Magnuson, T .

GENES & DEVELOPMENT, 2005, 19 (23) :2849-2861

[10] RSC, an essential, abundant chromatin-remodeling complex [J].

Cairns, BR ;

Lorch, Y ;

Li, Y ;

Zhang, MC ;

Lacomis, L ;

ErdjumentBromage, H ;

Tempst, P ;

Du, J ;

Laurent, B ;

Kornberg, RD .

CELL, 1996, 87 (07) :1249-1260

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