Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-γ

被引：175

作者：

Niino, M

Iwabuchi, K

Kikuchi, S

Ato, M

Morohashi, T

Ogata, A

Tashiro, K

Onoé, K

机构：

[1] Hokkaido Univ, Inst Med Genet, Res Sect Pathophysiol, Div Immunobiol,Kita Ku, Sapporo, Hokkaido 0600815, Japan

[2] Hokkaido Univ, Grad Sch Med, Dept Neurol, Kita Ku, Sapporo, Hokkaido 0608638, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 116卷 / 01期

关键词：

troglitazone; PPAR-gamma; experimental autoimmune encephalomyelitis; multiple sclerosis; myelin oligodendrocyte glycoprotein;

D O I：

10.1016/S0165-5728(01)00285-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, plays a critical role in adipocyte differentiation and glucose homeostasis. It has been implicated that PPAR-gamma functions as a regulator of cellular proliferation and inflammatory responses. In the present study, we examined whether troglitazone, a selective PPAR-gamma agonists, ameliorated experimental autoimmune encephalomyelitis (EAE) induced by administration of myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 in C57BL/6 mice. We found that troglitazone attenuated the inflammation and decreased the clinical symptoms. It was suggested that the amelioration was attributed to the attenuation of pro-inflammatory cytokine gene expressions. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：40 / 48

页数：9

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