Protein PTMs: post-translational modifications or pesky trouble makers?

被引：10

作者：

Bradshaw, Ralph A. ^{[1
]}

Medzihradszky, Katalin F. ^{[1
]}

Chalkley, Robert J. ^{[1
]}

机构：

[1] Univ San Francisco, Dept Pharmaceut Chem, NCRR Mass Spectrometry Facil, San Francisco, CA 94158 USA

来源：

JOURNAL OF MASS SPECTROMETRY | 2010年 / 45卷 / 10期

关键词：

PTMs; mass spectrometry; database searching; modification site assignment; phosphorylation;

D O I：

10.1002/jms.1786

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of protein post-translational modifications using mass spectrometry is an intensive area of proteomic research. This perspective discusses the current state of the field with respect to what can be achieved, the challenges encountered, most notably with modification site assignment, the reliability of the published results, consequences of unreliable data and what is needed to be done to improve the situation. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：1095 / 1097

页数：3

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