Regulatory enzymes of phosphatidylcholine biosynthesis: a personal perspective

被引:88
作者
Kent, C [1 ]
机构
[1] SBC GLOBAL, La Jolla, CA 92037 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2005年 / 1733卷 / 01期
基金
美国国家卫生研究院;
关键词
phosphatidylcholine; CDP-choline; phosphocholine; choline kinase; cytidylyltransferase;
D O I
10.1016/j.bbalip.2004.12.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phosphatidylcholine is a prominent constituent of eukaryotic and some prokaryotic membranes. This Perspective focuses on the two enzymes that regulate its biosynthesis, choline kinase and CTP:phosphocholine cytidylyltransferase. These enzymes are discussed with respect to their molecular properties, isoforms, enzymatic activities, and structures, and the possible molecular mechanisms by which they participate in replation of phosphatidylcholine levels in the cell. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:53 / 66
页数:14
相关论文
共 151 条
[61]   A CDP-choline pathway for phosphatidylcholine biosynthesis in Treponema denticola [J].
Kent, C ;
Gee, P ;
Lee, SY ;
Bian, X ;
Fenno, JC .
MOLECULAR MICROBIOLOGY, 2004, 51 (02) :471-481
[62]   OSMOTICALLY FRAGILE MUTANT OF BACILLUS-SUBTILIS WITH AN ACTIVE MEMBRANE-ASSOCIATED PHOSPHOLIPASE-A [J].
KENT, C ;
LENNARZ, WJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (10) :2793-&
[63]   APPROACH TO SELECTION OF MEMBRANE MUTANTS OF STAPHYLOCOCCUS-AUREUS BASED ON PH SENSITIVITY [J].
KENT, C ;
LENNARZ, WJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1972, 288 (01) :225-&
[64]   PROCEDURE FOR ISOLATION OF MUTANTS OF BACILLUS-SUBTILIS WITH DEFECTIVE CYTOPLASMIC MEMBRANES [J].
KENT, C ;
KRAG, SS ;
LENNARZ, WJ .
JOURNAL OF BACTERIOLOGY, 1973, 113 (02) :874-883
[65]  
KENT C, 1979, P NATL ACAD SCI USA, V76, P4474, DOI 10.1073/pnas.76.9.4474
[66]   Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae [J].
Kim, KH ;
Voelker, DR ;
Flocco, MT ;
Carman, GM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (12) :6844-6852
[67]   CRYSTAL-STRUCTURE OF THE CATALYTIC SUBUNIT OF CYCLIC ADENOSINE-MONOPHOSPHATE DEPENDENT PROTEIN-KINASE [J].
KNIGHTON, DR ;
ZHENG, JH ;
TENEYCK, LF ;
ASHFORD, VA ;
XUONG, NH ;
TAYLOR, SS ;
SOWADSKI, JM .
SCIENCE, 1991, 253 (5018) :407-414
[68]  
KRAG SS, 1975, J BIOL CHEM, V250, P2813
[69]   MprF-mediated lysinylation of phospholipids in Staphylococcus aureus leads to protection against oxygen-independent neutrophil killing [J].
Kristian, SA ;
Dürr, M ;
Van Strijp, JAG ;
Neumeister, B ;
Peschel, A .
INFECTION AND IMMUNITY, 2003, 71 (01) :546-549
[70]   PHOSPHOLIPASE-C FROM CLOSTRIDIUM-PERFRINGENS - PREPARATION AND CHARACTERIZATION OF HOMOGENEOUS ENZYME [J].
KRUG, EL ;
KENT, C .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1984, 231 (02) :400-410