RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

被引：1759

作者：

Yan, SD

Chen, X

Fu, J

Chen, M

Zhu, HJ

Roher, A

Slattery, T

Zhao, L

Nagashima, M

Morser, J

Migheli, A

Nawroth, P

Stern, D

Schmidt, AM

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT SURG,NEW YORK,NY 10032

[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT PHYSIOL & MED,NEW YORK,NY 10032

[3] SUN HLTH RES INST,SUN CITY,AZ 85372

[4] BERLEX BIOSCI,RICHMOND,CA 94804

[5] UNIV TURIN,I-10126 TURIN,ITALY

[6] UNIV HEIDELBERG,DEPT MED,D-69115 HEIDELBERG,GERMANY

来源：

NATURE | 1996年 / 382卷 / 6593期

关键词：

D O I：

10.1038/382685a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Amyloid-beta peptide is central to the pathology of Alzheimer's disease, because it is neurotoxic-directly by inducing oxidant stress, and indirectly by activating microglia. A specific cell-surface acceptor site that could focus its effects on target cells has been postulated but not identified. Here we present evidence that the receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia. increased expression of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death.

引用

页码：685 / 691

页数：7

共 45 条

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